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What information will be included in the Health Nucleus Genomics Reports?

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The Health Nucleus Genomics reports will include any medically significant results, as well as other non-clinical information such as traits and ancestry.  These reports provide insights on your genetic risk for certain illnesses or diseases. Your genes are not the only deciding factor for whether or not you will develop certain diseases and their influence varies depending on the disease.

Clinical:

The Health Nucleus Genomic Clinical Report provides you with information on known disease-associated genes, including:

  • ACMG 59 – This section consists of a list of 59 important genes as defined by the American College of Medical Genetics and Genomics (ACMG). If mutations are found in these genes, they should be reported to individuals because of their potential high medical importance and actionability.
  • Disease risks – This section identifies medically actionable genetic variants associated with significant current or future health risks across 70 complex diseases including:
    • Cancer
    • Neurological
    • Cardiovascular
    • Metabolic
    • Immunologic, Renal, Respiratory, Hematologic and Rheumatologic
  • Pharmacogenomics – This section provides a list of gene variants that helps to predict your responses to 40+ medications, including differences in drug effectiveness and side effects.
  • Carrier screening – This section helps you understand if you are a carrier of 242+ inherited conditions and is useful for family planning.

Insights:

The Health Nucleus Genomic Insights Report provides you with your genetic assessment to understand if your DNA has variants that can increase or decrease your risk for different health conditions including the following:

  • Human Leukocyte Antigen (HLA) Type – association with disease risk.
  • Bone health (e.g. Bone mineral density, osteoarthritis)
  • Cancer – inherited gene risk of known cancer-related genes (e.g. bladder, colorectal, esophageal, lung, melanoma, pancreatic, thyroid).
  • Cardiovascular health (e.g. Hypertension, Coronary artery disease [CAD], stroke, atrial fibrillation)
  • Connective tissue (Achilles tendinopathy)
  • Food intolerance and allergy (e.g. Lactose intolerance, celiac, allergies [peanut, shellfish, eggs, milk, etc.])
  • Infectious disease (e.g. Viral resistance)
  • Inflammatory and autoimmune disorders (e.g. Eczema, Rheumatoid arthritis, Systemic sclerosis, Inflammatory bowel disease [IBD])
  • Men’s health (e.g. Prostate cancer)
  • Mental health (e.g. Bipolar disorder, Major depressive disorder, Schizophrenia, Opioid addiction, risk seeking behavior, smoking behavior)
  • Metabolic health (e.g. Thyroid-stimulating hormone level, Type 2 diabetes, lipid levels, Alcohol flush, caffeine, gout, insulin insensitivity, caffeine metabolism, vitamin deficiencies)
  • Neurological (e.g. Alzheimer’s, Parkinson, Multiple sclerosis)
  • Respiratory (e.g. Asthma, COPD)
  • Sensory health (e.g. Exfoliation glaucoma, bitter taste perception, myopia, age-related macular degeneration)”
  • Personal Insights            
  • Variant list – Provides overview of all genetic variants that make you unique and any associated public information.
  • Ancestry – Learn about your family history and composition (Ancestral composition, maternal and paternal and Neanderthal)
  • Lifestyle traits – learn about some of the genes thought to be associated with addictive behavior, taste perception, endurance potential, laser eye surgery risk etc.
  • Traits and physical predictions – Predictions of personal traits including height, weight, eye color and skin color.
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